Epigenetic Reader Domain
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Epigenetic Reader Domain Inhibitors
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Epigenetic Reader Domain Agonists
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Epigenetic Reader Domain Antagonists
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Epigenetic Reader Domain Activators
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Epigenetic Reader Domain Modulators
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Epigenetic Reader Domain Chemicals
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Epigenetic Reader Domain Degraders
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Epigenetic Reader Domain Controls
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Epigenetic Reader Domain Substrate
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Epigenetic Reader Domain Ligands
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Epigenetic Reader Domain 関連製品 (448)
関連製品 (448)
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CeMMEC1 (Standard)
0 Images製品番号: HY-111445RCAS 番号: 440662-09-9
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EML 425 (Standard)
0 Images製品番号: HY-110263RCAS 番号: 1675821-32-5
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dBET1 (Standard)
0 ImagesdBET1 (Standard) is the analytical standard of dBET1 (HY-101838). This product is intended for research and analytical applications. dBET1 is a PROTAC connected by ligands for Cereblon and BRD4 with an EC50 of 430 nM. dBET1 is a PROTAC that composes of (+)-JQ1 (HY-13030) linked to NSC 527179 (HY-14658) with a linker.
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PROTAC BET Degrader-1 (Standard)
0 Images製品番号: HY-103633RCAS 番号: 2093386-22-0PROTAC BET Degrader-1 (Standard) is the analytical standard of PROTAC BET Degrader-1 (HY-103633). This product is intended for research and analytical applications. PROTAC BET Degrader-1 is a BRD2/BRD3/BRD4 PROTAC degrader. PROTAC BET Degrader-1 inhibits the growth of acute leukemia cells. PROTAC BET Degrader-1 is applicable to the research of acute leukemia.
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KG-501 (Standard)
0 Images製品番号: HY-103299RCAS 番号: 18228-17-6別名: Naphthol AS-E phosphate (Standard)
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NVS-CECR2-1 (Standard)
0 Images製品番号: HY-110374RCAS 番号: 1992047-61-6NVS-CECR2-1 (Standard) is the analytical standard of NVS-CECR2-1 (HY-110374). This product is intended for research and analytical applications. NVS-CECR2-1, a non-BET family Bromodomain (BRD) inhibitor, is a potent and selective cat eye syndrome chromosome region, candidate 2 (CECR2) inhibitor. NVS-CECR2-1 binds to CECR2 BRD with high affinity (IC50=47 nM; Kd=80 nM). NVS-CECR2-1 exhibits cytotoxic activity and induces apoptosis against various cancer cells by targeting CECR2 as well as via CECR2-independent mechanism. NVS-CECR2-1 is a chemical probe.
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GNE-272 (Standard)
0 Images製品番号: HY-100726RCAS 番号: 1936428-93-1GNE-272 (Standard) is the analytical standard of GNE-272 (HY-100726). This product is intended for research and analytical applications. GNE-272 is a potent and selective CBP/EP300 inhibitor with IC50 values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4, respectively. GNE-272 is also a selective in vivo probe for CBP/EP300.
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Hexamethylene bisacetamide (Standard)
0 Images別名: HMBA (Standard)Hexamethylene bisacetamide (Standard) is the analytical standard of Hexamethylene bisacetamide. This product is intended for research and analytical applications. Hexamethylene bisacetamide (HMBA) is a differentiation inducer and selective bromine domain inhibitor that can differentiate across the blood-brain barrier. Hexamethylene bisacetamide can induce tumor cell differentiation and inhibit cell proliferation, showing antitumor activity. Hexamethylene bisacetamide induces apoptosis by Notch1, Bcl-2 and p53 signaling pathways. In addition, Hexamethylene bisacetamide improves the obesity phenotype of mice.
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RMM23
0 Images製品番号: HY-170219CAS 番号: 3113265-82-7RMM23 is an inhibitor targeting PfBDP1 with a Kd value of 1.24 μM. RMM23 against the wild-type strains 3D7 and NF54, and the multidrug-resistant K1 strain in vitro blood stage, with EC50 values of 18 μM, 14 μM, 20 μM, respectively .
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(R)-I-BET762 carboxylic acid (Standard)
0 Images別名: (R)-Molibresib carboxylic acid (Standard); (R)-GSK525762A carboxylic acid (Standard); (R)-PROTAC BRD4-binding moiety 2 (Standard)(R)-I-BET762 carboxylic acid (Standard) is the analytical standard of (R)-I-BET762 carboxylic acid (HY-107443A). This product is intended for research and analytical applications. (R)-I-BET762 carboxylic acid, the R-enantiomer of I-BET762 carboxylic acid (HY-107443). I-BET762 carboxylic acid is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid is a BRD4 inhibitor with a pIC50 value of 5.1.
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(+)-JQ-1 (Standard)
0 Images製品番号: HY-13030RCAS 番号: 1268524-70-4別名: JQ1 (Standard)(+)-JQ-1 (Standard) is the analytical standard of (+)-JQ-1 (HY-13030). This product is intended for research and analytical applications. (+)-JQ-1 (JQ1), a chemical probe, is a potent, specific, CNS-penetrant and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)). (+)-JQ-1 also activates autophagy.
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Alobresib (Standard)
0 Images製品番号: HY-109050RCAS 番号: 1637771-14-2別名: GS-5829 (Standard)Alobresib (Standard) is the analytical standard of Alobresib (HY-109050). This product is intended for research and analytical applications. Alobresib (GS-5829) is a BET bromodomain inhibitor, which represents a highly effective therapeutics agent against recurrent/chemotherapy resistant uterine serous carcinoma (USC) overexpressing c-Myc. Alobresib can be used in the metastatic castration-resistant prostate cancer (mCRPC) research.
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Inobrodib (Standard)
0 Images製品番号: HY-111784RCAS 番号: 2222941-37-7別名: CCS1477 (Standard)Inobrodib (Standard) is the analytical standard of Inobrodib (HY-111784). This product is intended for research and analytical applications. Inobrodib (CCS1477) is an orally active, potent, and selective inhibitor of the p300/CBP bromodomain. Inobrodib binds to p300 and CBP with Kd values of 1.3 and 1.7 nM, respectively, and with 170/130-fold selectivity compared with BRD4 with a Kd of 222 nM. CCS1477 inhibits cell proliferation in prostate cancer cell lines and decreases androgen receptor (AR)- and C-MYC-regulated gene expression.
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AZD5153 6-Hydroxy-2-naphthoic acid (Standard)
0 Images製品番号: HY-100653ARCAS 番号: 1869912-40-2AZD5153 (6-Hydroxy-2-naphthoic acid) (Standard) is the analytical standard of AZD5153 (6-Hydroxy-2-naphthoic acid) (HY-100653A). This product is intended for research and analytical applications. AZD5153 6-Hydroxy-2-naphthoic acid is the 6-Hydroxy-2-naphthoic acid of AZD5153. AZD5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor; disrupts BRD4 with an IC50 of 1.7 nM.
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MI-2-2 (Standard)
0 Images製品番号: HY-108350RCAS 番号: 1454920-20-7MI-2-2 (Standard) is the analytical standard of MI-2-2 (HY-108350). This product is intended for research and analytical applications. MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation.
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CBP/p300-IN-1 (Standard)
0 Images製品番号: HY-111420RCAS 番号: 2443789-32-8CBP/p300-IN-1 (Standard) is the analytical standard of CBP/p300-IN-1 (HY-111420). This product is intended for research and analytical applications. CBP/p300-IN-1 is a CBP/EP300 bromodomain inhibitor.
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EP300/CBP-IN-1
0 Images製品番号: HY-160260CAS 番号: 2638507-71-6EP300/CBP-IN-1 (compound 172) is a potent EP300/CBP inhibitor with IC50s of 2.3 nM and 2.1 nM for CBP BRD and EP300 BRD, respectively. EP300/CBP-IN-1 has the inhibitory effect on the proliferation of prostate cancer CWR22RV1 cells.
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BRD4 Inhibitor-37
0 ImagesBRD4 Inhibitor-37 is a compound with anticancer activity that has inhibitory activity against BRD4. BRD4 Inhibitor-37 has an IC50 of approximately 0.05-0.1 μM in binding assays and shows a GI50 of 0.1-0.3 μM in cell-based assays. The effect of BRD4 Inhibitor-37 on c-Myc, a downstream protein of BRD4, has been validated, demonstrating its ability to intervene in this signaling pathway. BRD4 Inhibitor-37 exhibits selectivity among five different bromodomain proteins, enhancing its potential as a BET protein inhibitor.
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SNIPER(BRD)-1 (Standard)
0 Images製品番号: HY-111875RCAS 番号: 2095244-54-3SNIPER(BRD)-1 (Standard) is the analytical standard of SNIPER(BRD)-1 (HY-111875). This product is intended for research and analytical applications. SNIPER(BRD)-1 is a SNIPER degrader of BRD4, cIAP1 and XIAP. SNIPER(BRD)-1 has IC50 values of 6.8 nM, 17 nM and 49 nM for cIAP1, cIAP2 and XIAP, respectively. SNIPER(BRD)-1 can be used for cancer research. (Blue: LCL161 (HY-15518); Black: linker (HY-W008005); Pink: (+)-JQ-1 (HY-13030))
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GSK6853 (Standard)
0 Images製品番号: HY-100220RCAS 番号: 1910124-24-1GSK6853 (Standard) is the analytical standard of GSK6853 (HY-100220). This product is intended for research and analytical applications. GSK6853, a chemical probe, is a potent and selective inhibitor of the BRPF1 bromodomain. GSK6853 shows excellent BRPF1 potency (pKd = 9.5) and greater than 1600-fold selectivity over all other bromodomains.
